Contact information
mark.middleton@oncology.ox.ac.uk
+44 (0)1865 617331 (PA)
Taryn Hastings
PAtoMarkMiddleton@oncology.ox.ac.uk
Research Themes
Genome Integrity & Epigenetics (Collaborator)
Immunology (Collaborator)
COLLABORATORS
- Professor Xin Lu, Ludwig Institute Oxford Branch
- Professor Ben Fairfax, Department of Oncology
- Professor Brian Nicholson, Primary Care Health Sciences
- Dr Yoshiaki Nakamura
- Dr Andrew Soltan, Department of Oncology
Mark Middleton
Head, Department of Oncology
- Professor of Experimental Cancer Medicine
- Consultant Medical Oncologist, Oxford Cancer and Haematology Centre
Early Phase, Melanoma and Upper Gastrointestinal Cancer Trials
Research Summary
I’m interested in the development of new drugs to treat cancer, principally immunotherapies. To achieve this I work with scientists and drug companies to validate drug targets, optimise candidate molecules and design both pre-clinical testing programmes and early clinical trials, with the aim of bringing these trials to patients here in Oxford.
Biography
Mark trained in Medicine at the Universities of Cambridge and Oxford, and in Oncology at the Christie Hospital and University of Manchester. His clinical and research interests are in new cancer drug development and the treatment of upper GI cancers and melanoma. He has been Chief or Principal Investigator on over 100 trials and is closely involved in the development of new therapies including DNA repair, immune checkpoint and kinase inhibitors, ImmTACs and oncolytic viruses. Mark is Director of the CRUK Oxford Centre and Head of Oncology at the University of Oxford, where he founded the Early Phase Clinical Trials Unit.
GROUP MEMBERS
I deliver trials through the Early Phase Clinical Trials Unit and with the Oncology Clinical Trials Office. My translational research is conducted through collaborations and I co-supervise several students:
- Rebecca Wiltshire (with Dr Michele Peters)
- Alina Popa (with Immunocore)
- Fei Gao (with Profs Graham Ogg and Tao Dong)
- Rob Watson (with Dr Ben Fairfax).
Group Alumni & Next Destinations
- Nicholas Coupe, DPhil Student (with V Macaulay) – Consultant Medical Oncologist, OUH
- Ioannis Karydis, DPhil Student (with V Cerundolo) – Senior Lecturer, University of Southampton
- Richard Owen, DPhil Student (with X Lu) – Academic Surgeon, OUH and University of Oxford
- Jonathon Kwok, DPhil Student (with P Klenerman) – CEO, Infinitopes
- Vinton Cheng, DPhil Student with (N Sibson – Academic Clinical Lecturer, University of Leeds
Key publications
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Validity and timeliness of cancer diagnosis data collected during a prospective cohort study and reported by the English and Welsh cancer registries: a retrospective, comparative analysis.
Journal article
Jackson A. et al, (2024), Lancet Oncol, 25, 1476 - 1486
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Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma.
Journal article
Carroll TM. et al, (2023), Cancer Cell, 41, 1222 - 1241.e7
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Multi-cancer early detection test in symptomatic patients referred for cancer investigation in England and Wales (SYMPLIFY): a large-scale, observational cohort study.
Journal article
Nicholson BD. et al, (2023), Lancet Oncol
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Tebentafusp in combination with durvalumab and/or tremelimumab in patients with metastatic cutaneous melanoma: a phase 1 study.
Journal article
Hamid O. et al, (2023), J Immunother Cancer, 11
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IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma.
Journal article
Taylor CA. et al, (2022), Nat Med
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Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma.
Journal article
Middleton MR. et al, (2020), Clin Cancer Res, 26, 5869 - 5878
Recent publications
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RP1 Combined With Nivolumab in Advanced Anti-PD-1-Failed Melanoma (IGNYTE).
Journal article
Wong MK. et al, (2025), J Clin Oncol
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Preferences for multi-cancer tests (MCTs) in primary care: discrete choice experiments of general practitioners and the general public in England
Journal article
Buckell J. et al, (2025), British Journal of Cancer
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CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade
Journal article
Milotay G. et al, (2025), Nature Medicine
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Longitudinal Genomic Analysis to Fine-Tune Targeted Therapy: Results of the Phase II LOGIC 2 Trial in Patients With BRAF V600-Mutant Metastatic Melanoma.
Journal article
Dummer R. et al, (2025), Clin Cancer Res
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Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity.
Journal article
Go S. et al, (2024), Elife, 13